Detection of Epitestosterone Doping by Isotope Ratio Mass Spectrometry
نویسندگان
چکیده
منابع مشابه
Detection of epitestosterone doping by isotope ratio mass spectrometry.
BACKGROUND Epitestosterone is prohibited by sport authorities because its administration will lower the urinary testosterone/epitestosterone ratio, a marker of testosterone administration. A definitive method for detecting epitestosterone administration is needed. METHODS We developed a gas chromatography-combustion-isotope ratio mass spectrometry method for measuring the delta(13)C values fo...
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Isotope Ratio Mass Spectrometry (IRMS) is a specialized technique used to provide information about the geographic, chemical, and biological origins of substances. The ability to determine the source of an organic substance stems from the relative isotopic abundances of the elements which comprise the material. Because the isotope ratios of elements such as carbon, hydrogen, oxygen, sulfur, and...
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RECEIVED for review February 21, 1978. Accepted June 19, 1978. NMR spectra since two distinct peaks (6 -3.38, 3.78 ppm) caused by these protons are observed in CDCA vs. only one peak (6 -3.45 ppm) caused by the same protons in UDCA. T h e fingerprint region of the spectrum (6 1-2.5 ppm) and the relative position of the CIS methyl peak with respect to tha t of the doublet caused by the Cpl methy...
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The administration of synthetic steroid copies is one of the most important issues facing sports. Doping control laboratories accredited by the World Anti-Doping Agency (WADA) require methods of analysis that allow endogenous steroids to be distinguished from their synthetic analogs in urine. The ability to measure isotope distribution at natural abundance with high accuracy and precision has i...
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The metabolic effect of multiple oral testosterone undecanoate (TU) doses over 4 weeks was assessed in seven voluntary men. The protocol was designed to detect accumulation of the substance by choosing the appropriate spot urines collections time and to study the urinary clearance of the substance after weeks of treatment. Urines were analysed by a new GC/C/isotope ratio mass spectrometry (IRMS...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2002
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/48.4.629